Practical Tips

CBD inhibits the ENT1 adenosine transporter and enhances adenosine signaling. What exactly was measured, on which animals, and what is still unknown.

What really happens to CBD after swallowing: the first-pass effect, the impact of a fatty meal, and what no one has measured about oral bioavailability.

THC tolerance involves desensitization and internalization of the CB1 receptor. What cell, animal, and PET imaging studies have shown in regular users.

Endocannabinoidome is an extended network of signaling lipids. Where did this name come from, what do PEA, OEA, DHEA, and SEA do, and what has been measured in humans and what in animals.

Helichrysum produces cannabigerolic acid independently of hemp, beta-caryophyllene binds to the CB2 receptor, and Radula liverwort provides a THC analog. What do studies say.

Which animals have CB1 and CB2 receptors, and which do not. Hydra, insects, dogs, and humans in light of research on the evolution of the endocannabinoid system.

Runner's high is no longer attributed to endorphins. What was really measured in studies on anandamide, PEA, and oleamide after exercise and what is still unknown.

THCV blocks the CB1 receptor, but at higher doses it begins to stimulate it. What did the pilot study on 62 patients with type 2 diabetes measure and what did it not measure.

Inflammation does not extinguish on its own. Lipoxins and resolvins actively close it, and the CB2 receptor shifts macrophages to repair. What do studies say about this.

Anandamide was isolated from the brain of a pig in 1992. Who discovered what and in what order, how this lipid works, and why the mechanism of CBD needed correction.