Scientific analysis: does self-medication with cannabis increase paranoia? The THC/CBD mechanism, key studies (D'Souza, Freeman, Marconi), risk groups, and safe practices.
Synthetic cannabinoids ("Spice", K2) are up to 100x stronger than THC. EMCDDA notes 224 substances under monitoring. Full report on dangers 2026.
CBD and THC in anxiety disorders: mechanism (5-HT1A, CB1/CB2, amygdala, GABA), biphasic response of THC, dosing 25-600 mg of CBD, interactions with SSRIs and benzodiazepines, state of research 2015-2026, and Polish legal context.
Depression and cannabis: the mechanism of action of CBD through 5-HT1A, the HPA axis, and neurogenesis, the quality of clinical evidence 2019-2025, the risks of THC, interactions with SSRIs, SNRIs, and MAOIs through CYP2C19/3A4, and why CBD does not replace psychiatry.
PTSD affects 3-5% of the adult Polish population and up to 54% of refugees from Ukraine. Standard treatment is trauma-focused CBT, EMDR, and SSRIs. CBD as a potential complementary support, study Berger 2022, Jetly 2015.
CBD in schizophrenia, research on the antipsychotic effects of cannabis - Medical and health applications
CBD for social phobia - studies, dosing, safety. Bergamaschi 2011: 600 mg of CBD reduced anxiety before public speaking in 80% of participants.
CBD and ADHD - research analysis 2026. Neurobiology, interactions with methylphenidate, dosing. Cooper 2017: 30% reduction in impulsivity in the Sativex group (PMC).
CBD for depression 2026: 5-HT1A, neurogenesis, and anhedonia. Depressive disorders affect 1.2 million Poles (NFZ 2024). What do studies say and how to use CBD.
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