Tilray Sirius (Cannabis flos Tilray): lineage of chemdawg and caryophyllene from the registry

What is Tilray Sirius and what do the collected records say about its origin?

Tilray Sirius is a dried flower product from the manufacturer Tilray, listed in the Polish pharmacy registry as a single entry. Collected sources indicate its lineage as follows: chemdawg crossed with alien tech. Aside from the lineage and the assignment of the leading terpene, there is little information available about this entry, and that is the correct answer, not a gap to be filled.

The lineage appears in three places at once. The service weedstrain.com directly states the parent pair chemdawg and alien tech for this trade name. Wiki medbud.wiki has a separate page for this manufacturer’s strain. Meanwhile, the Leafly catalog describes the strain alien dawg with a note that Tilray sells it under its own trade name Sirius. The third record uniquely explains the discrepancy in names between catalogs and is the only one that does not have a counterpart in the Polish register of medicinal products.

In the list from which this cluster derives its pharmacy composition, the trade name Sirius appears twice: once with the manufacturer S-LAB, and once with the manufacturer's prefix as Tilray Sirius. The project treats these two entries as separate listings and describes them as such. This text pertains exclusively to the Tilray entry. Whether both stand behind the same plant material is not resolved by the records: one has the lineage of recorded parents, while the other has none at all, and none of the collected sources equate them or negate that equality. The entry for the second manufacturer is described in this cluster osobny wpis.

Which manufacturers supply this strain to Polish pharmacies?

One. In the pharmacy registry on which this cluster is based, the Tilray Sirius entry appears once and comes from Tilray, a manufacturer that offers fourteen strains in Polish pharmacies. The second version of the same entry is not recorded, so there is nothing to compare between manufacturers. The table below shows what each of the records separately conveys about this entry.

The two zeros in the middle of the table mean exactly what they say. The terpene composition of this entry is not publicly documented: both databases from which this cluster derives profiles have no entries under this name, and the only trace remains the assignment of the leading terpene in the pharmacy registry. Such an assignment indicates what the registry's editorial team considered the primary note, and does not replace the results of sample analysis. Listing the terpene here would mean transferring numbers collected under another entry to this one, so there is no list here.

The number of manufacturers under one name changes over time and is not a characteristic of the strain. The permit for the admission of raw material is issued for a specified period, the manufacturer may change along with the supplier of the material, and the wholesaler can remain empty for weeks without any formal movement. Therefore, we keep the inventory status in one place, not in every entry about the strain: the current list is maintained by a comprehensive summary of available strains. Tilray.

How does Tilray Sirius smell and taste?

The source description lists four notes for this entry: camphor, spicy, peppery, and pine. This is provided by one source, the same one that maintains the profile composition for it, so it is a report from a single service, not the result of organoleptic testing conducted according to an announced protocol. The second source does not record either scent or taste.

The profile composition described for this entry includes eight compounds: caryophyllene, myrcene, nerolidol, limonene, humulene, pinene, linalool and bisabolol. The highest share is attributed to caryophyllene, which aligns with the leading terpene from the pharmacopoeia. We do not record shares as numbers because the source provides them without a denominator.

Caryophyllene is responsible for the peppery and spicy notes. This same compound gives heat to black pepper, is found in cloves and hops, and it is what creates the impression that commercial descriptions usually refer to as woody or earthy. Thus, two of the four noted notes align with the first compound in the composition.

Descriptions of aroma in Polish strain listings are editorial labels, not results of organoleptic testing conducted according to an announced protocol. Two services can assign completely different adjectives to the same registration entry because each compiles its own list of acceptable terms and decides how many to use. Additionally, the aroma depends on the batch and how long the dried flower has been stored and in what conditions, as terpenes are volatile and diminish over time. Those who expect a consistent aroma from the strain name are expecting more from the plant material than it can provide.

How long does it take for this strain to take effect and how long does the effect last?

This is determined by the method of administration, not by the fact that this particular entry is named as such. For Tilray Sirius itself, no one has measured either the onset of effects or their duration. What can be stated honestly pertains to the method of intake of the raw material and is the same for the entire group.

The route of administration determines the course more than the variety itself. After vaporization, the substance passes from the lungs to the blood almost immediately, so the first sensations appear after a few minutes, the intensity increases for another ten to thirty minutes, and the whole effect lasts for two to four hours. After ingestion, the raw material first passes through the intestine and liver, so the first sensations are awaited from half an hour to two hours, and the episode can last six, sometimes eight hours. Hence the most common mistake with oral administration: anyone who thinks nothing is happening after thirty minutes and takes another dose will receive both doses at once. The above ranges describe the route of administration, not this variety; pharmacokinetic studies for a single cultivar have not been published.

For this entry, there is not even material for a cautious assumption. Since there is neither a published composition nor a personal measurement behind it, merely assigning the leading terpene from the list does not allow for guessing whether the experience deviates from the above in any direction.

What has been demonstrated, and what has not been demonstrated about the effects of this strain?

Nothing has been demonstrated for the strain itself. There is no study in which volunteers were given this specific entry and the effects measured. Everything below pertains to caryophyllene as a single chemical compound, assigned to this strain by the pharmacopoeia, not by a published measurement of the sample's composition.

Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A published in 2008 in the Proceedings of the National Academy of Sciences (PNAS) a study with identifier PMID:18574142, in which (E)-caryophyllene selectively bound to the CB2 receptor (Ki = 155 nM) and inhibited carrageenan-induced paw swelling in wild-type mice, but not in mice lacking the CB2 receptor (Cnr2-/-), indicating a CB2-dependent mechanism; the study did not include any anxiety tests. Model: mouse (in vivo) and test tube (receptor binding, human cells).

Six years later, Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A described in European Neuropsychopharmacology, under identifier PMID:24210682, that oral caryophyllene reduced the late inflammatory phase of pain in mice in the formalin test in a CB2 receptor-dependent manner, with no effect on the early phase; in a neuropathic pain model, it alleviated thermal hyperalgesia and mechanical allodynia without developing tolerance with chronic administration. Model: rodent (mouse).

The boundaries of these studies must be stated clearly. In neither of the two studies was caryophyllene tested on humans or in inhaled form from dried flower; both studies concern oral or systemic administration in mice in pain and inflammation models, not sleep or mood. Everything else circulating about this strain is manufacturer catalog material or patient reports, thus describing impressions rather than measured effects.

What side effects have been reported for this strain?

None specifically for it. The reporting system does not recognize trade names of strains, so under the name Tilray Sirius, there is not a single report and there will not be until events are described by the product's batch number. The following therefore pertains to dried flower as a group, not this single entry.

Reports of adverse effects are collected for medicinal products with a batch number, not for the strain name, so the following pertains to hemp dried flower as a group of raw materials. The most frequently reported symptoms are dry mouth, red eyes, and increased heart rate. Dizziness upon rapid standing, daytime drowsiness, and temporary worsening of short-term memory are less frequently described, as well as anxiety that increases with dosage. A separate issue is medications taken concurrently, especially sedatives and those affecting coagulation: their assessment requires knowledge of the entire list of preparations, not just the description of the plant. We do not provide the frequency of these symptoms numerically, as public compilations for hemp dried flower in Poland do not separate them by individual products.

The lineage or assigned terpene does not change anything here. A report enters the system with the medicinal product's batch number, and the strain name does not carry a batch number, so breaking such a collection down into individual pharmacy entries remains beyond the reach of anyone working solely with public sources.

What is known about the vaporization temperature for this strain?

Less than what popular tables promise. For this entry, no one has announced a recommended range, and the only hard numbers that can be cited here pertain to caryophyllene itself and come from a chemical database, not from a study on vaporization of dried flower by a patient. There is not a single such study in the evidence base of this cluster.

The public PubChem database lists caryophyllene under CID 5281515 and provides a boiling point of 256-259 °C at a pressure of 760 mm Hg. A second entry in the same database mentions 130 °C, but at 14 mm Hg, which is under pressure several dozen times lower than atmospheric pressure. Comparing both numbers in one column yields a result that lacks physical sense, and this is how most terpene temperature tables circulating online are created.

The boiling point is not, in fact, the threshold at which the terpene begins to evaporate. Evaporation also occurs below that point, and its rate increases smoothly with temperature, so aiming the setting at one selected compound remains a superficial endeavor. Additionally, the number on the device describes the heating element or air, not the temperature of the dried flower itself, which cools with each draw and heats unevenly. This is elaborated in a separate entry about the evaporation of terpenes, while caryophyllene itself is dedicated to post about this terpeneThe method of consuming the raw material is determined by the attending physician.

Which strains from Polish pharmacies are related to it?

One: GMO. The pedigree graph of this cluster connects both entries through a common parent, which is chemdawg, and aside from this one pair, it does not show any other connection with Tilray Sirius among the strains available in Polish pharmacies. The second parent, alien tech, does not appear in the graph with anything else.

GMO has recorded parents as chemdawg and girl scout cookies, so exactly half of the parental pair is common. It is supplied to pharmacies by a different manufacturer than this strain, which clearly shows that kinship and supplier are two independent orders. GMO itself is described in this cluster osobny wpis.

Further down, the graph becomes sparser than the names would suggest. Chemango Kush has GMO among its parents, meaning it is one generation further and is not a sibling. Krypton has a parent recorded as chemdawg 91, and that is a separate entry in the graph, not the same as chemdawg, so there are no connections from here. Gorilla Glue niesie w rodowodzie chem’s sister: a common element in the name with zero common parent.

The matter of the trade name itself stands separately. The second entry listed under the name Sirius has its pedigree recorded as unknown, so the graph does not connect it with anything, including this strain. A common name in this context is not a premise for kinship and does not work the other way around: its absence does not exclude anything.

Frequently asked questions about the Tilray Sirius strain.

Is Tilray Sirius the same strain as Sirius?

The records do not clarify this. The pharmacy list maintains both names as two separate entries with different producers, and the pedigree graph has recorded parents only for one of them. This cluster describes them as two separate entries and should be read as such: as two records, not as an established identity or an established difference.

What is the pedigree of Tilray Sirius?

The collected sources record the parental pair as chemdawg crossed with alien tech. One of them adds that the producer operates under this trade name for a strain known elsewhere as alien dawg. The Polish register of medicinal products does not have a pedigree field, so this is a catalog entry, not an official one.

How many producers supply this strain to Polish pharmacies?

One, Tilray. The number of producers associated with the strain name changes over time, as licenses expire, and entries may be withdrawn and reintroduced. The current state of availability is maintained by a collective overview of strains, not this entry.

Is the terpene composition of this strain known?

Yes, but it is described by only one source. It lists eight compounds, with caryophyllene having the highest share, which aligns with the leading terpene from the pharmacy list. The second database under this name does not have an entry, so there is no confirmation from the other side.

Has this strain been studied in humans?

No. No study has been published in which this specific entry was given to humans. The research cited in this text pertains to a single terpene administered to mice and cell cultures, not to dried flower inhaled by a patient.

Can hemp dried flower be purchased without a prescription?

No. Dried flower is a pharmaceutical raw material dispensed by a doctor's prescription in the Rpw category, and the application and method of consumption are determined by the attending physician.

The material is informational and does not replace medical advice nor encourage the use of any product.

Editorial text: redakcja ubucha.pl