The entourage effect, or the mutual complementation of compounds found in cannabis, is a frequently used argument for using full-spectrum preparations. The benefits of this synergy are well-documented, and the concept was coined by Raphael Mechoulam himself. The specific combination of cannabinoids CBD, CBG, and THC, which is the subject of a growing body of research, is also worth noting. We describe a selection below.

What is CBG?

CBG (cannabigerol) is one of the hemp cannabinoids. Like CBD and THC, it is produced by plants of the Cannabis family and has the ability to bind to endocannabinoid receptors in the human body (and other mammals). Although it was isolated in 1964, broader research into its properties only began a few years ago.

CBG – “the mother of cannabinoids”

CBG in its acidic form, or CBGA, is the precursor to most cannabinoids. As the cannabis plant grows, CBGA branches into three main cannabinoids: CBDA, or cannabidiolic acid; CBCA, or cannabichromenic acid; and THCA, or tetrahydrocannabinolic acid.

Under the influence of temperature, acid forms cannabinoids are transformed into the forms we are better familiar with, and it is this form that activates the CB1 and CB2 receptors in our body. Therefore, CBG is sometimes called the “mother of cannabinoids”.

CBG itself is also a “full-fledged cannabinoid” that has specific properties: it has analgesic and anti-inflammatory properties, balances the hormonal system, and regulates appetite.

CBD, CBG, THC – the benefits of combining

Research shows that when CBD is combined with THC, CBG, and other cannabinoids, may provide more therapeutic benefits. This relationship is called the "entourage effect." This concept was presented by Professor Raphael Mechoulam. The researcher stated that cannabinoids work It is best when they are served together, then they complement each other and bring out the best in each other.

For example, CBG can reduce the side effects of the psychoactive effects of THC while enhancing its positive properties., e.g. antiemetic, anticonvulsant, anti-inflammatory and analgesic effects.

CBD, CBG, and THC – how do they affect the body when administered together? Selected scientific studies.

It deserves special attention CBD connection and CBG. Let's take a look at the scientific studies that have focused on the potential use of these cannabinoids in various situations.

According to the authors article published in 2023, there is an unmet need for painkillers that effectively relieve pain after fractures. Due to their mechanism of action and side effects, this need is not met by nonsteroidal anti-inflammatory drugs (they hinder healing by inhibiting the "necessary" inflammation) and opioids (they are highly addictive).

Researchers examined the analgesic efficacy of two cannabinoids, CBD and CBG, in a mouse model of tibial fracture. Both CBD and CBG normalized pain sensitivity to all tested stimuli, and their analgesic effects were comparable to those of NSAIDs. At the same time, CBD and CBG promoted bone healing in all phases of healing. The data collected in this study suggest that CBD and CBG are therapeutic agents that can replace NSAIDs in the treatment of fractures. pain management post-traumatic.

Scientists they showed, that a higher concentration of CBD and CGB in medical cannabis may increase the effectiveness and tolerance of THC in patients who respond less well to treatment with preparations containing the psychoactive cannabinoid.

According to research, CBD and CBG have the ability to prevent the abnormal cell growth and proliferation that occurs in cancer. Although further research is needed, the results of existing studies are promising.

Other studies have shown that both CBD and CBG have antispasmodic properties, meaning they can help alleviate or eliminate seizures.

Capacity hemp for pain relief is well known, as are many side effects, including drowsiness. In one of research The ability of THC, CBD, and CBG, used individually and in combination, to block pain responses was analyzed. The cannabinoids were tested on lab-grown sensory neurons (tissue cultures) that respond to pain stimuli, such as the compound responsible for the heat in chili peppers—capsaicin.

It has been shown that THC, CBG and CBD When used individually, they were able to block capsaicin responses in sensory neurons, but THC, CBD, and CBG combined in a 1:1:1 ratio were more effective. This combination also increased the effectiveness of THC at a lower dose, which may make it possible to reduce the concentration of the psychoactive cannabinoid in medicinal herb. The results of this study pave the way for clinical trials aimed at developing more effective cannabis-based pain medications.

We encourage you to read the article in which we describe new research results on mechanism of action of CBD in inflammation.

Sources:

https://www.mdpi.com/1420-3049/26/18/5601

https://www.sciencedirect.com/science/article/pii/S0367326X21000903

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627890/