CBD: Does it help treat depression?

Depression Research – CBD Effects

There are speculations that CBD may be particularly helpful in treating depression, as it possesses most of the properties of THC, but without the psychoactive effects. A study published in 2018 analyzed the effects of CBD on depression in rodents, concluding that a single dose can produce a rapid and lasting antidepressant effect. A 2014 review of animal studies also demonstrated CBD's anti-anxiety and antidepressant effects. This may be directly related to serotonin levels in the central nervous system, where the highest concentration of CB1 receptors activated by cannabinoids like CBD is found. Therefore, it appears that preparations containing CBD may prove to be a promising therapy for people experiencing conditions anxiety and depression, as well as sleep problems.

CBD dosage

First of all – before you start use CBD preparations For the treatment of depression, consult your doctor who will help you decide which preparation is best for you and how to dose it. General recommendations for CBD dosage for depression are very approximate, as there isn't yet enough research to accurately estimate them.

• A study published in 2018 found that a single dose of CBD (10 mg/kg to 30 mg/kg) demonstrated antidepressant effects lasting about seven days. However, it's important to note that this study was conducted on rodents, not humans.
• There is also a human study that found that a single dose of 10 mg/kg of body weight was similarly effective – however, the study involved people who suffered from anxiety disorders, not depression. 
• another dosing study CBD for various conditions and symptoms, such as seizures, anxiety, and Parkinson's disease, the active daily dosage range has been found to be 1 to 50 mg of CBD for every kilogram of body weight – studies that used higher doses tended to have better therapeutic outcomes. 

Given that there is not much data on this topic, limited clinical data examining the use of preparations can be used. CBD for depression and social anxiety. The study authors recommend starting the dosage at 10 mg/kg body weight, gradually increasing the dose according to individual needs. 

How do cannabinoids work on depression?

The endocannabinoid system (ECS) exists in all vertebrates and helps regulate key functions such as sleep, pain, and appetite. The human body produces its own cannabinoids, called endocannabinoids, which modulate and activate its various functions—at the same time, they can also be activated by with the help of cannabinoids derived from hemp, which interact with CB1 and CB1 receptors, which are found throughout our bodies. The endocannabinoid system is involved in mood regulation, and according to scientists, CB1 receptors, found primarily in the brain, may have a real impact on the occurrence and prevention of depression.